abstract：:Secophalloidin (SPH) is known to cause in cardiac myofibrils force without Ca(2+) (half-maximal effect approximately 2 mM) followed by irreversible loss of Ca(2+)-activated force. At maximal Ca(2+) activation, SPH increases force (half-maximal effect < 0.1 mM). We found that SPH at low concentration (0.5 mM) did not c...

journal_title：Journal of muscle research and cell motility

authors： Bukatina AE,Sieck GC,Campbell KB,Belohlavek M

更新日期：2009-01-01 00:00:00

abstract：:It is generally thought that the rapid relaxation of fast muscles is facilitated by the Ca(2+) binding protein parvalbumin (Parv). Indeed superfast swimbladder (SWB) muscle of toadfish contains the largest concentration of this protein ever observed (up to 1.5 mM). At 15 degrees C toadfish perform a 100 Hz call, 400 m...

journal_title：Journal of muscle research and cell motility

authors： Tikunov BA,Rome LC

更新日期：2009-01-01 00:00:00

abstract：:Phosphorylation of skeletal myosin regulatory light chain (RLC) occurs in fatigue and may play a role in the inhibition of shortening velocities observed in vivo. Forces and shortening velocities were measured in permeabilized rabbit psoas fibers with either phosphorylated or dephosphorylated RLCs and in the presence ...

journal_title：Journal of muscle research and cell motility

authors： Stewart M,Franks-Skiba K,Cooke R

更新日期：2009-01-01 00:00:00

abstract：:Myomesin-I (also known as Skelemin) is a approximately 185 kDa protein, which is highly expressed in striated muscle. It contains the prototypic class-I (type-III fibronectin) and class-II (C2-immunoglobulin) motifs. Previous studies have shown the presence of Myomesin-I at the M-line of the sarcomere, where it is tho...

journal_title：Journal of muscle research and cell motility

authors： Reddy KB,Fox JE,Price MG,Kulkarni S,Gupta S,Das B,Smith DM

更新日期：2008-01-01 00:00:00

abstract：:A balanced redox status is necessary to optimize force production in contractile apparatus, where free radicals generated by skeletal muscle are involved in some basic physiological processes like excitation-contraction coupling. Protein glutathionylation has a key role in redox regulation of proteins and signal trans...

journal_title：Journal of muscle research and cell motility

authors： Passarelli C,Petrini S,Pastore A,Bonetto V,Sale P,Gaeta LM,Tozzi G,Bertini E,Canepari M,Rossi R,Piemonte F

更新日期：2008-01-01 00:00:00

abstract：:Muscle development involves a complex sequence of time and spatially regulated cellular events leading to the formation of highly specialised syncytial muscle cells displaying a common feature, the capacity of contraction. Analyses of mechanisms controlling muscle development reveals that the main steps of muscle form...

journal_title：Journal of muscle research and cell motility

authors： Maqbool T,Jagla K

更新日期：2007-01-01 00:00:00

abstract：:The ability for muscle to repeatedly generate force is limited by fatigue. The cellular mechanisms behind muscle fatigue are complex and potentially include breakdown at many points along the excitation-contraction pathway. In this paper we construct a mathematical model of the skeletal muscle excitation-contraction p...

journal_title：Journal of muscle research and cell motility

authors： Shorten PR,O'Callaghan P,Davidson JB,Soboleva TK

更新日期：2007-01-01 00:00:00

abstract：:Cleavage of vertebrate muscle tropomyosin by bacterial Omp T produces an amino-terminally truncated product (residues 7-284). The proteolysed protein, which is resolved from the parent by electrophoresis in the presence of sodium dodecylsulphate, can be generated from a variety of striated and smooth muscle tropomyosi...

journal_title：Journal of muscle research and cell motility

authors： Goonasekara CL,Gallivan LJ,Jackman DM,Heeley DH

更新日期：2007-01-01 00:00:00

abstract：:Striated muscle fine structure began to be really understood following a comprehensive survey of the matter carried out by William Bowman in the late 1830s. The publications resulting from such a study, the first of which earned for the author a precocious election as Fellow of the Royal Society, are herewith examined...

journal_title：Journal of muscle research and cell motility

authors： Frixione E

更新日期：2006-01-01 00:00:00

abstract：:Skeletal muscle fibers exhibit plasticity of their physiological and biochemical properties in response to the firing pattern from the innervating motor neuron. In particular, the gene expression pattern generally characteristic of a slow twitch fiber can be induced in a fast twitch fiber by chronic slow fiber type el...

journal_title：Journal of muscle research and cell motility

authors： Shen T,Liu Y,Randall WR,Schneider MF

更新日期：2006-01-01 00:00:00

abstract：:In Drosophila melanogaster two high molecular weight tropomyosin isoforms, historically named heavy troponins (TnH-33 and TnH-34), are encoded by the Tm1 tropomyosin gene. They are specifically expressed in the indirect flight muscles (IFM). Their N-termini are conventional and complete tropomyosin sequences, but thei...

journal_title：Journal of muscle research and cell motility

authors： Mateos J,Herranz R,Domingo A,Sparrow J,Marco R

更新日期：2006-01-01 00:00:00

abstract：:Stretchin-klp is a newly described protein in Drosophila indirect flight muscles (IFM) that migrates on SDS gels as two distinct components of approximately 225 and 231 kD. Although the larger isoform is IFM specific, the smaller stretchin-klp isoform is expressed not only in IFM, but also in wild-type tissues of the ...

journal_title：Journal of muscle research and cell motility

authors： Patel SR,Saide JD

更新日期：2005-01-01 00:00:00

abstract：:Twitchin, also called mini-titin, is structurally related to the giant elastic protein connectin/titin, and has been found in not only striated but also smooth muscles of bivalves. Many bivalve smooth muscles such as byssus retractor muscles and the opaque part of adductor muscles are known as catch muscles that can m...

journal_title：Journal of muscle research and cell motility

authors： Tsutsui Y,Yoshio M,Oiwa K,Yamada A

更新日期：2005-01-01 00:00:00

abstract：:The cellular function of the giant protein titin in striated muscle is a major focus of scientific attention. Particularly, its role in passive mechanics has been extensively investigated. In strong contrast, the structural details of this filament are very poorly understood. To date, only a handful of atomic models f...

journal_title：Journal of muscle research and cell motility

authors： Marino M,Svergun DI,Kreplak L,Konarev PV,Maco B,Labeit D,Mayans O

更新日期：2005-01-01 00:00:00

abstract：:We examined the tension responses induced by rapid temperature-jumps (T-jumps) applied at different times during twitch and tetanic contractions in small intact fibre bundles (5-10 fibres) isolated from a fast foot muscle (flexor hallucis brevis) of the rat. A rapid T-jump of 2-4 degrees C was induced by a 0.2 ms infr...

journal_title：Journal of muscle research and cell motility

authors： Coupland ME,Pinniger GJ,Ranatunga KW

更新日期：2005-01-01 00:00:00

abstract：:The myosin II motor from Dictyostelium discoideum has been engineered to contain single tryptophan residues at strategic locations to probe movements of switch 1 and switch 2. The tryptophan residue at W501 probes movement of the relay helix and indirectly reports on switch 2 movement. This probe suggests that there i...

journal_title：Journal of muscle research and cell motility

authors： Málnási-Csizmadia A,Dickens JL,Zeng W,Bagshaw CR

更新日期：2005-01-01 00:00:00

abstract：:The phenotypic expression of cardiomyopathy is greatly influenced by extrinsic factors other than intrinsic genetic defects, such as environmental stress. Exercise is assumed to be an important extrinsic factor, since sudden death is sometimes seen during exercise in young patients with hypertrophic cardiomyopathy (HC...

journal_title：Journal of muscle research and cell motility

authors： Tatsuguchi M,Hiratsuka E,Machida S,Nishikawa T,Imamura S,Shimizu S,Nishimura M,Komuro I,Furutani Y,Furutani M,Nagao H,Komatsu K,Kasanuki H,Matsuoka R

更新日期：2004-01-01 00:00:00

abstract：:The effects of two amino acids, arginine which has a positively charged side-chain and glutamate which has a negatively charged side-chain on the Ca2+-activation properties of the contractile apparatus were examined in four structurally and functionally different types of skeletal muscle; long- and short-sarcomere fib...

journal_title：Journal of muscle research and cell motility

authors： Jame DW,West JM,Dooley PC,Stephenson DG

更新日期：2004-01-01 00:00:00

abstract：:The kinetics of smooth muscle are thought to be partially determined by the level of the expression of the 7 amino acid insert, SMB, in the myosin heavy chain, as SMB is generally expressed at higher levels in faster smooth muscle. In this study, we determined the role of this insert on shortening velocity and force r...

journal_title：Journal of muscle research and cell motility

authors： Karagiannis P,Babu GJ,Periasamy M,Brozovich FV

更新日期：2004-01-01 00:00:00

abstract：:Telokin, a 17 kDa smooth muscle specific protein, consists of the C-terminal domain of MLCK, is phosphorylated by PKA and PKG at Ser13 in vivo (Wu et al. (1998) J Biol Chem 273: 11362-11369; Walker et al. (2001) J. Biol Chem 276: 24519-24524) and is proposed to induce Ca2+-desensitization through activation of myosin ...

journal_title：Journal of muscle research and cell motility

authors： Choudhury N,Khromov AS,Somlyo AP,Somlyo AV

更新日期：2004-01-01 00:00:00

abstract：:Our current understanding of the structure of the thin filaments of muscle and the molecular mechanism by which thin filaments regulate muscle contraction are reviewed and discussed. We focus, in particular, on the crucial role played by Jean Hanson in these studies and on later contributions from those whose work she...

journal_title：Journal of muscle research and cell motility

authors： Lehman W,Craig R

更新日期：2004-01-01 00:00:00

abstract：:MagFluo-4 fluorescence (Ca2+) transients associated with action potentials were measured in intact muscle fibres, manually dissected from toads ( Leptodactylus insularis ) or enzymatically dissociated from mice. In toads, the decay phase of the Ca2+ transients is described by a single exponential with a time constant ...

journal_title：Journal of muscle research and cell motility

authors： Caputo C,Bolaños P,Gonzalez A

更新日期：2004-01-01 00:00:00

abstract：:The optimal utilization of energy substrates in muscle fibers is of primary importance for muscle contraction and whole body physiology. This study aimed to investigate the age-related changes in some indicators of glucose catabolism and fatty acid oxidation in muscles of growing rabbits. Longissimus lumborum (fast-tw...

journal_title：Journal of muscle research and cell motility

authors： Gondret F,Damon M,Jadhao SB,Houdebine LM,Herpin P,Hocquette JF

更新日期：2004-01-01 00:00:00

abstract：:Clenbuterol is a beta2-adrenoceptor agonist primarily used for treating bronchospasm and alleviating the symptoms of chronic obstructive pulmonary disease (COPD) in the horse. In other species (rats, mice, sheep, and cattle), chronic high doses of clenbuterol (typically in the milligram per kilogram body weight range)...

journal_title：Journal of muscle research and cell motility

authors： Plant DR,Kearns CF,McKeever KH,Lynch GS

更新日期：2003-01-01 00:00:00

abstract：:The L-type Ca2+ channel in skeletal muscle (alpha1S) is essential for excitation-contraction (EC) coupling. Previous studies using chimeras composed of alpha1S together with alpha1C or alpha1M demonstrated the importance of the alpha1S II-III loop and of a smaller subdomain (residues 720-764; 'ECC') in skeletal EC cou...

journal_title：Journal of muscle research and cell motility

authors： Wilkens CM,Beam KG

更新日期：2003-01-01 00:00:00

abstract：:The sarcomere of striated muscle is a very efficient machine transforming chemical energy into movement. However, a wrong distribution of the generated forces may lead to self-destruction of the engine itself. A well-known example for this is eccentric contraction (elongation of the sarcomere in the activated state), ...

journal_title：Journal of muscle research and cell motility

authors： Agarkova I,Ehler E,Lange S,Schoenauer R,Perriard JC

更新日期：2003-01-01 00:00:00

abstract：:To date, there has been no report of rat TnC purification, despite the rat being an animal commonly used in physiological studies of mammalian muscle. In this study we isolated the fast and slow Troponin C isoforms from rat extensor digitorum longus (23 microg TnC/g wet weight) and soleus (17.6 microg TnC/g wet weight...

journal_title：Journal of muscle research and cell motility

authors： O'Connell B,Stephenson GM

更新日期：2003-01-01 00:00:00

abstract：:In this study alterations are characterized which occur, in myocardial force development morphological appearance and protein composition, during the development of cardiac hypertrophy and heart failure in monocrotaline (MCT) treated rats. The transition from cardiac hypertrophy to heart failure was studied by compari...

journal_title：Journal of muscle research and cell motility

authors： Korstjens IJ,Rouws CH,van der Laarse WJ,Van der Zee L,Stienen GJ

更新日期：2002-01-01 00:00:00

abstract：:The term 'microtubule dynamics' is often used to describe assembly/disassembly characteristics of this important cytoskeletal polymer. The ability to image microtubules in live Dictyostelium cells has revealed additional dynamic components, acting on the individual assembled tubules. At least two separate forces are i...

journal_title：Journal of muscle research and cell motility

authors： Koonce MP,Khodjakov A

更新日期：2002-01-01 00:00:00

abstract：:Cytokinesis is the mechanical process that allows the simplest unit of life, the cell, to divide, propagating itself. To divide, the cell converts chemical energy into mechanical energy to produce force. This process is thought to be active, due in large part to the mechanochemistry of the myosin-II ATPase. The cell's...

journal_title：Journal of muscle research and cell motility

authors： Robinson DN,Girard KD,Octtaviani E,Reichl EM

更新日期：2002-01-01 00:00:00

abstract：:Proteins containing disintegrin domains play a variety of roles in regulating processes involving adhesion, migration and cell type specification during development of many metazoan organisms. Most disintegrin domain containing proteins belong to the ADAM (a disintegrin and a metalloprotease) family of proteins that a...

journal_title：Journal of muscle research and cell motility

authors： Blumberg DD,Ho HN,Petty CL,Varney TR,Gandham S

更新日期：2002-01-01 00:00:00

abstract：:Nebulin is an integral protein of skeletal muscle thin filaments and probably acts as a ruler for the thin filament length. Cardiac muscles of higher vertebrates have been shown earlier to lack nebulin. Instead in human and chicken cardiac muscle the much smaller protein nebulette replaces nebulin. Since nebulette is ...

journal_title：Journal of muscle research and cell motility

authors： Fock U,Hinssen H

更新日期：2002-01-01 00:00:00

abstract：:Protein kinase C (PKC) is known to play important roles in integrin mediated cell spreading. This study investigated the role of PKC during insulin mediated muscle cell spreading, which was independent of integrin alpha5. We found that PKC-alpha becomes active and localise to membrane during insulin mediated cell spre...

journal_title：Journal of muscle research and cell motility

authors： Goel HL,Dey CS

更新日期：2002-01-01 00:00:00

abstract：:The details of the global and local structure and function of titin, a giant filamentous intrasarcomeric protein are largely undiscovered. Here we discuss a combination of bulk-solution and novel single-molecule techniques that may lend unique insights into titin's molecular dynamic, structural and mechanical characte...

journal_title：Journal of muscle research and cell motility

authors： Kellermayer MS,Grama L

更新日期：2002-01-01 00:00:00

abstract：:We investigated the expression of neuronal nitric oxide synthase (nNOS) and dystrophin in the regenerating skeletal muscles of rats after cardiotoxin-induced myonecrosis by immunohistochemical studies and western blot analysis. In normal muscles, nNOS was moderately immunostained on type 2B fibers, but was faintly imm...

journal_title：Journal of muscle research and cell motility

authors： Hoshino S,Ohkoshi N,Ishii A,Shoji S

更新日期：2002-01-01 00:00:00

abstract：:This study investigated the effects of the protein kinase A (PKA) inhibitor, H-89, in mechanically-skinned muscle fibres and intact muscle fibres, in order to determine whether PKA phosphorylation is essential for normal excitation-contraction (E-C) coupling. In skinned EDL fibres of the rat, force responses to depola...

journal_title：Journal of muscle research and cell motility

authors： Blazev R,Hussain M,Bakker AJ,Head SI,Lamb GD

更新日期：2001-01-01 00:00:00

abstract：:A popular part of many athletes pre-game regime is to stretch. We examined whether a pre-injury stretching protocol could prevent acute contraction-induced injury. The in situ extensor digitorum longus (EDL) muscle of an anesthetized mouse (80 mg/kg intra-peritoneal) was used. Damage to the muscle from eccentric contr...

journal_title：Journal of muscle research and cell motility

authors： Black JD,Stevens ED

更新日期：2001-01-01 00:00:00

abstract：:Several factors have an influence on the improvement of muscle activity and motor co-ordination of mammals during post-natal development. One of them is voltage sensitive L-type calcium channel function. In striated muscles of adult mammals these channels are located in T-tubule membranes thus linking the on-coming ac...

journal_title：Journal of muscle research and cell motility

authors： Mänttäri S,Pyörnilä A,Harjula R,Järvilehto M

更新日期：2001-01-01 00:00:00

abstract：:The effects of a ramp stretch (amplitude <6% muscle fibre length (L0), speed < 13L0 s(-1)) on twitch tension and twitch tension re-development were examined in intact mammalian (rat) fast and slow muscle fibre bundles. The experiments were done in vitro at 20 degrees C and at an initial sarcomere length of 2.68 microm...

journal_title：Journal of muscle research and cell motility

authors： Mutungi G,Ranatunga KW

更新日期：2001-01-01 00:00:00

abstract：:Changes in the isoform patterns of myosin heavy chains (MHC) and Ca2+-ATPase (SERCA) were studied in long-term (72 days) denervated slow-twitch soleus muscles of euthyroid and hyperthyroid rabbits. MHC isoforms were separated electrophoretically. SERCA isoforms were assessed by electrophoretic separation of the trypsi...

journal_title：Journal of muscle research and cell motility

authors： Hämäläinen N,Pette D

更新日期：2001-01-01 00:00:00